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US 11,254,720 B2Granted
Methods and systems for designing and/or characterizing soluble lipidated ligand agents
AssigneesOn Target Therapeutics LLC, Trustees of Tufts College, Tufts Medical Center, Inc.
InventorsCharles Cohen, Krishna Kumar, Jamie Raudensky Doyle, Alan S. Kopin
Life of this patent
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Abstract
The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.
Claims5
A method of treating neuropathic pain, the method comprising administering to a subject in need thereof a soluble lipidated ligand agent that has the following structure:
- wherein one or more of the Y, S, and A are D-amino acids, and wherein T1c represents (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid.
Dependencies are inferred from the claim text.