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US 11,254,712 B2Granted
Chimeric molecules and uses thereof
AssigneeThe University of Queensland
InventorsKeith Joseph Chappell, Daniel Watterson, Paul Robert Young
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AssigneeThe University of Queensland
InventorsKeith Joseph Chappell, Daniel Watterson, Paul Robert Young
Estimating the term…
Disclosed are chimeric polypeptides based on viral membrane fusion proteins. More particularly, the present invention discloses chimeric polypeptides that comprise a virion surface exposed portion of a viral fusion protein and a heterologous structure-stabilizing moiety, and to complexes of those chimeric polypeptides. The present invention also discloses the use of these complexes in compositions and methods for eliciting an immune response to a fusion protein of an enveloped virus, or complex of the fusion protein, and/or for treating or preventing an enveloped virus infection. The present invention further discloses the use of the heterologous structure-stabilizing moiety for oligomerizing heterologous molecules of interest.
A chimeric polypeptide comprising an enveloped virus fusion ectodomain polypeptide and a heterologous, structure-stabilizing moiety comprising complementary first heptad repeat (HR1) and second heptad repeat (HR2) regions that associate with each other under conditions suitable for their association to form an anti-parallel, two-helix bundle, wherein the structure-stabilizing moiety is operably connected downstream of the ectodomain polypeptide.
Dependencies are inferred from the claim text.