Combination stirrer
AssigneeHoffmann-La Roche Inc.
InventorsMarco Jenzsch, Max Lechner, Michael Pohlscheidt, Christoph Reese, Alexander Scholz, Hermann Tebbe
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Abstract
The present patent application describes a stirrer comprising a combination of at least one axially-conveying element and at least one radially-conveying element relative to the rotary shaft of the stirrer wherein the largest diameter of the at least one axially-conveying element is equal to or less than the inner diameter di of the radially-conveying element. In one embodiment the stirrer according to the invention is a combination of one anchor stirrer with at least one inclined-blade stirrer. Furthermore the use of the stirrer according to the invention for the culture of cells in a dialysis method is described.
Claims8
An agitator configured to improve mixing and mass transport within a cell cultivation vessel, comprising:
- a shaft comprising a shaft axis;
- one anchor impeller comprising at least two opposing stirrer blades, wherein the stirrer blades of the anchor impeller have no pitch with respect to the shaft axis;
- and
- one or more inclined-blade stirrers each comprising at least two stirrer blades, wherein the stirrer blades of each of the inclined-blade stirrers have a pitch with respect to the shaft axis,
- wherein the stirrer blades of the anchor impeller are parallel to each other and to the shaft axis,
- wherein an outer diameter of each inclined-blade stirrer is equal to or less than an inner diameter of the anchor impeller, the outer diameter of each inclined-blade stirrer is a maximum distance between tips of opposing stirrer blades of each inclined-blade stirrer and the inner diameter of the anchor impeller is a minimum distance between inner edges of opposing stirrer blades of the anchor impeller,
- wherein all inclined-blade stirrers are individually connected to the anchor impeller,
- wherein all inclined-blade stirrers are located within the anchor impeller, and
- wherein the anchor impeller and the inclined-blade stirrers all have a fixed spatial orientation relative to each other with regard to distance and angle.
Dependencies are inferred from the claim text.