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US 11,253,582 B2Granted
Chlamydia-activated B cell platforms and methods thereof
AssigneeOhio State Innovation Foundation
InventorsThomas Cherpes, Rodolfo Vicetti Miguel
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Abstract
Disclosed herein is a Chlamydia-activated B cell (CAB) platform. Also disclosed is a method of enhancing a population of B cells, comprising exposing said B cells to Chlamydia spp. under conditions suitable to enhance the population of B cells, such that expansion and differentiation of said B cells takes place, and said B cells are exposed or crosslinked to an antigen. Also disclosed are methods of producing said CABs, and treating a subject in need thereof with said CABs.
Claims7
A method for producing activated, antigen-presenting Chlamydia-activated B cells, the method comprising:
- a. obtaining B cells from a subject;
- b. exposing the B cells from step a) to a whole, inactivated Chlamydia spp. bacterium;
- c. exposing or crosslinking the B cells of step b) to a desired antigen, wherein the antigen is not derived from Chlamydia spp., thereby obtaining activated, antigen-presenting Chlamydia-activated B cells (CABs).
Dependencies are inferred from the claim text.