Antithrombotic medical material using nickel titanium alloy
AssigneeToray Industries, Inc.
InventorsSo Kakiyama, Koji Kadowaki, Kazuhiro Tanahashi
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Abstract
A medical material uses a nickel-titanium alloy wherein a polyelectrolyte has a reduced thickness while a sufficient amount of an antithrombogenic compound for production of a therapeutic effect is supported. The medical material in which a porous surface is formed on a nickel-titanium alloy to allow infiltration of a polyelectrolyte into the pores, to thereby reduce the thickness of the polyelectrolyte exposed on the surface of the nickel-titanium alloy while allowing supporting of a sufficient amount of an antithrombogenic compound due to contribution of the polyelectrolyte infiltrate.
Claims5
An antithrombogenic medical material comprising:
- a nickel-titanium alloy;
- a polyelectrolyte bound to a surface of the nickel-titanium alloy;
- and
- an antithrombogenic compound bound to the polyelectrolyte, the antithrombogenic compound having a charge opposite to the charge of the polyelectrolyte;
- wherein
- Formula (1) is satisfied according to measurement using X-ray photoelectron spectroscopy (XPS), and
- Formula (2) is satisfied according to measurement using Auger electron spectroscopy (AES)
- Tiratio,XPS>2 (1)
- wherein in Formula (1), Tiratio, XPS represents the abundance ratio (atomic percentage) of titanium element to the abundance of total elements as measured by XPS on a surface of the medical material
- Cratio,AES≥7 (2)
- wherein in Formula (2), Cratio, AES represents the abundance ratio (atomic percentage) of carbon element to the abundance of total elements on the surface of the medical material after being subjected to argon ion etching to 20 nm in terms of SiO2.
Dependencies are inferred from the claim text.