Rapid freezing, storage, transport, and thawing system for containers of biopharmaceutical products

A system for freezing, storing, transporting, and thawing biopharmaceutical product, the system comprising a stationary equipment and a plurality of movable pallets, each of the plurality of movable pallets being configured to carry one or more protective packaging, each protective packaging being adapted for receiving therein a single-use flexible bag,

• the stationary equipment comprising a gas circulating unit comprising at least a blower and configured to cause selectively a circulation of cold gas or warm gas, from a pull inlet toward at least a blow outlet, to carry out selectively either a freezing of the biopharmaceutical product, or a thawing of the biopharmaceutical product,
• wherein there is provided at least a first side plenum having one or more gas conveying channel(s) therein, configured to be fluidly coupled to the blow outlet of the gas circulating unit,
• the first side plenum having a plurality of outlet ports-directed toward an interior volume of the pallet, wherein the gas circulates substantially in a horizontal direction in the interior volume of the pallet,
• wherein there is further provided a second side plenum having a plurality of inlet ports, wherein the outlet ports of the first side plenum blow gas while the inlet ports of the second side plenum pulls gas and return the gas to the gas circulating unit, where the inlet ports are arranged opposite the outlet ports in the horizontal direction,
• the side plenums being arranged on the stationary equipment,
• wherein the cold gas or warm gas circulates along top and bottom sides of each of the single-use flexible bag,
• so that either freezing of the biopharmaceutical product is achieved when the gas caused to circulate is cold or thawing of the biopharmaceutical product is achieved when the gas caused to circulate is warm, wherein the one or more pallet(s) comprises a shaker device provided at a base of the pallet and imparting a reciprocating movement to the whole pallet.

A system for freezing, storing, transporting, and thawing biopharmaceutical product, the system comprising a stationary equipment and a plurality of movable pallets, each of the plurality of pallets being configured to carry one or more protective packaging, each protective packaging being adapted for receiving therein a single-use flexible bag,

• the stationary equipment comprising a gas circulating unit comprising at least a blower and configured to cause selectively a circulation of cold gas or warm gas, from a pull inlet toward at least a blow outlet, to carry out selectively either a freezing of the biopharmaceutical product, or a thawing of the biopharmaceutical product,
• wherein there is provided at least a first side plenum having one or more gas conveying channel(s) therein, configured to be fluidly coupled to the blow outlet of the gas circulating unit,
• the first side plenum having a plurality of outlet ports-directed toward an interior volume of each of the plurality of movable pallets, wherein the gas circulates substantially in a horizontal direction in the interior volume of each of the plurality of movable pallets,
• wherein there is further provided a second side plenum having a plurality of inlet ports, wherein the outlet ports of the first side plenum blow gas while the inlet ports of the second side plenum pulls gas and return the gas to the gas circulating unit, where the inlet ports are arranged opposite the outlet ports in the horizontal direction,
• the side plenums being arranged on each of the plurality of pallets,
• wherein the cold gas or warm gas circulates along top and bottom sides of each of the single-use flexible bag,
• so that either freezing of the biopharmaceutical product is achieved when the gas caused to circulate is cold or thawing of the biopharmaceutical product is achieved when the gas caused to circulate is warm, wherein the one or more pallet(s) comprises a shaker device provided at a base of the pallet and imparting a reciprocating movement to the whole pallet.