Dietary supplement compositions including cannabidiol formulations having enhanced bioavailability with sustained time release and enhanced organoleptics, and methods of making same

A method of preparing a dietary supplement composition, said method comprising the steps of:

• generating a cannabinoid phase by stirring an active ingredient comprising one or both of cannabinoid and cannabinoid compound in a first container;
• generating a phospholipid phase by stirring a phospholipid compound in a second container;
• adding said cannabinoid phase and said phospholipid phase in vessel;
• performing a homogenizing step by mixing said cannabinoid phase and said phospholipid phase for a predetermined time so as to form a cannabinoid-phospholipid composition having a plurality of liposomal vesicles of said phospholipid compound, said liposomal vesicles having said one or both the cannabinoid and cannabinoid compound incorporated therein;
• wherein a concentration of said one or both the cannabinoid and cannabinoid compound incorporated in said liposomal vesicles in said cannabinoid-phospholipid composition is about 10 mass % to 25 mass %;
• and
• wherein the method step of generating the cannabinoid phase by stirring the active ingredient comprises the step of adding at least one of α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin to said active ingredient.

A method of preparing a dietary supplement composition, said method comprising the steps of:

• generating a cyclodextrin-cannabinoid phase by kneading cannabinoid oil mixed with a cyclodextrin and distilled water;
• rolling the cyclodextrin-cannabinoid phase into a plurality of cylindrical rolls;
• storing said cylindrical rolls of said cyclodextrin-cannabinoid phase at ambient temperature for a period of about 24 hours;
• adding distilled water to the cylindrical rolls of said cyclodextrin-cannabinoid phase,
• performing a first homogenizing step by mixing distilled water and said cylindrical rolls of the cyclodextrin-cannabinoid phase using a homogenizer operated at progressively increasing speeds from about 8000 rpm to 100000 rpm for a time period of about 90 minutes so as to form a cyclodextrin-cannabinoid composition;
• adding an additional ingredient selected from the group consisting of a rice bran, mannitol and trehalose to said cyclodextrin-cannabinoid composition;
• performing a second stage of homogenizing said additional ingredient and said cyclodextrin-cannabinoid composition using a homogenizer operated at progressively increasing speeds from about 8000 rpm to 10,0000 rpm for a time period of about 90 minutes so as to form a cyclodextrin-cannabinoid-additional ingredient mixture;
• adding phospholipid compound to said cyclodextrin-cannabinoid-additional ingredient mixture;
• and
• performing a third stage of homogenization by blending of a mixture of said phospholipid compound and said cyclodextrin-cannabinoid-additional ingredient mixture by using a homogenizer so as form a cannabinoid-cyclodextrin-cannabinoid-additional ingredient-phospholipid composition having a plurality of liposomal vesicles of said phospholipid compound, said liposomal vesicles having said cyclodextrin-cannabinoid composition incorporated therein;
• wherein said liposomal vesicles have coating of said additional ingredient formed around said liposomal vesicles.