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US 11,249,094 B2Granted
Astrocyte traumatome and neurotrauma biomarkers
AssigneeThe Regents of the University of California
InventorsIna-Beate Wanner, Joseph A. Loo
Life of this patent
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AssigneeThe Regents of the University of California
InventorsIna-Beate Wanner, Joseph A. Loo
Estimating the term…
A method for detection or monitoring status of traumatic brain injury (TBI) and/or spinal cord injury (SCI) in a subject is provided. In one embodiment, the method comprises contacting a specimen of bodily fluid obtained from the subject with reagents for assaying for a marker of TBI selected from aldolase C (ALDOC) and brain lipid binding protein (BLBP/FABP7), or a trauma-specific break down product (BDP) of ALDOC or BLBP/FABP7. The method further comprises measuring the amount of marker present in the specimen as compared to a control sample, and determining the presence of TBI or SCI when an elevated amount of marker is present in the specimen compared to the control sample. Optionally, the method further comprises measuring the amount of glutamine synthetase (GS), astrocytic phosphoprotein PEA-15 (PEA15), αB-crystallin (CRYAB/HSP27), a trauma-specific proteolytic cleavage product of ALDOC, GS, PEA15, or CRYAB, or any combination of two or more thereof.
A method for detection and treatment of traumatic brain injury (TBI) in a pediatric subject, the method comprising:
A method of treating traumatic brain injury (TBI) in a subject by measuring the levels of markers that distinguish between TBI and chronic neurodegenerative disease, the method comprising:
Dependencies are inferred from the claim text.