Techniques for checking state of analyzers
AssigneeRoche Diagnostics Operations, Inc.
InventorsStefan Quint, Benjamin Tiemann, Florian Schweinberger, Martin Stingl
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Abstract
An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
Claims15
An automated method of monitoring a state of an analyzer including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, the method comprising:
- monitoring an electrospray ionization current of the ESI source;
- and
- identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, wherein one of the conditions is a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
Dependencies are inferred from the claim text.