Anti-human transferrin receptor antibody permeating blood-brain barrier
AssigneeJCR Pharmaceuticals Co., Ltd.
InventorsHiroyuki Sonoda, Kenichi Takahashi
Life of this patent
Estimating the term…
Abstract
Disclosed are a means to convert compounds having physiological or pharmacological activity and unable to pass through the blood-brain barrier into a form that allows them to pass through the blood-brain barrier, and compounds converted thereby. The means is an anti-human transferrin receptor antibody and the converted compounds are molecular conjugates between physiologically active protein or pharmacologically active low-molecular-weight compounds and an anti-human transferrin receptor antibody.
Claims6
A fusion protein which penetrates the blood brain barrier following administration to a human comprising a humanized anti-human transferrin receptor (anti-hTfR) antibody amino acid sequence and a human iduronate 2-sulfatase amino acid sequence, wherein the fusion protein is selected from (1) to (3) below:
- (1) the fusion protein, wherein the humanized anti-hTfR antibody light chain has the amino acid sequence set forth as SEQ ID NO:164, and wherein the humanized anti-hTfR antibody heavy chain is linked, on the C-terminal side thereof and via a linker sequence Gly-Ser, to the human iduronate 2-sulfatase, and the whole linked heavy chain has the amino acid sequence set forth as SEQ ID NO:247,
- (2) the fusion protein, wherein the humanized anti-hTfR antibody light chain has the amino acid sequence set forth as SEQ ID NO:180, and wherein the humanized anti-hTfR antibody heavy chain is linked, on the C-terminal side thereof and via a linker sequence Gly-Ser, to the human iduronate 2-sulfatase, and the whole linked heavy chain has the amino acid sequence set forth as SEQ ID NO:249, and
- (3) the fusion protein, wherein the humanized anti-hTfR antibody light chain has the amino acid sequence set forth as SEQ ID NO:196, and wherein the humanized anti-hTfR antibody heavy chain is linked, on the C-terminal side thereof and via a linker sequence Gly-Ser, to the human iduronate 2-sulfatase, and the whole linked heavy chain has the amino acid sequence set forth as SEQ ID NO:251.
Dependencies are inferred from the claim text.