Binding moieties for biofilm remediation
AssigneeTrellis Bioscience, LLC
InventorsLawrence M. Kauvar, Stefan Ryser, Angeles Estelles, Reyna J. Simon, Lauren Opremcak Bakaletz, Steven David Goodman
Life of this patent
Estimating the term…
Abstract
Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies secreted by human B lymphocytes. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
Claims11
A method to obtain antibodies immunoreactive with integration host factor (IHF) protein or B cells that secrete antibodies immunoreactive with IHF protein which method comprises assessing whether an antibody present in a patient sample binds to a peptide that consists of the amino acid sequence IEYLSDKYHLSKQDTK (SEQ ID NO:49) (positions 10-25 of the Haemophilus influenzae IHFα chain) or the amino acid sequence RDKSSRPGRNPKTGDVVAARSARR (SEQ ID NO:50) (positions 56-78 of the Haemophilus influenzae IHFα chain), or homologs thereof, and isolating an antibody that binds to the peptide.
Dependencies are inferred from the claim text.