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US 11,248,021 B2Granted
Bone delivery conjugates and method of using same to target proteins to bone
AssigneeAlexion Pharmaceuticals, Inc.
InventorsPhilippe Crine, Guy Boileau, Isabelle Lemire, Thomas P. Loisel
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Abstract
A bone delivery conjugate having a structure selected from the group consisting of: A) X-Dn-Y-protein-Z; and B) Z-protein-Y-Dn-X, wherein X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and Dn is a poly aspartate wherein n=10 to 16. Compositions comprising same and methods of use thereof.
Claims8
A bone delivery conjugate having a structure selected from the group consisting of:
- A) X-Dn-Y-protein-Z;
- and
- B) Z-protein-Y-Dn-X,
- wherein the protein is a soluble alkaline phosphatase (sALP) that is not a soluble form of a tissue non-specific alkaline phosphatase;
- wherein X is absent or is an amino acid sequence of at least one amino acid;
- Y is absent or is an amino acid sequence of at least one amino acid;
- Z is absent or is an amino acid sequence of at least one amino acid;
- and
- Dn is a poly aspartate wherein n=10 to 16.
6 more elements
Dependencies are inferred from the claim text.