Compositions and methods for adhesion to surfaces
AssigneeRevBio, Inc.
InventorsBrian J. Hess, George W. Kay
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions and their methods of use to adhere (e.g., in wet and dry environments) a variety of materials together.
Claims19
An adhesive composition comprising:
- (i) a multivalent metal salt selected from one of a tetracalcium phosphate or tricalcium phosphate;
- (ii) an aqueous medium;
- (iii) citric acid or malonic acid;
- (iv) calcium citrate;
- (v) phosphoserine;
- wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa.
A kit comprising an adhesive composition comprising:
- (i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
- (ii) an aqueous medium;
- (iii) citric acid or malonic acid;
- (iv) calcium citrate;
- (v) phosphoserine;
- wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa.
A method of filling a bone void resulting from the removal of a bone cyst, granuloma, abscess, or similar bone defect, wherein bone void is crestal, central, or lateral to the alveolar ridge or another portion of the facial skeleton, the method comprising:
- a) preparing an adhesive composition comprising:
- (i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
- (ii) an aqueous medium;
- (iii) citric acid or malonic acid;
- (iv) calcium citrate;
- (v) phosphoserine;
- wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa;
- and
- b) placing the composition into said bone void;
- wherein the composition hardens and/or cures in less than about 30 minutes.
A method of filling a bone void resulting from a prepared extraction site, the method comprising:
- a) preparing an adhesive composition comprising:
- (i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
- (ii) an aqueous medium;
- (iii) citric acid or malonic acid;
- (iv) calcium citrate;
- (v) phosphoserine;
- wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa
- and
- b) placing the composition into said bone void;
- wherein the composition hardens and/or cures in less than about 30 minutes.
A method of filling a gap or discontinuity of bone resulting from a congenital condition, trauma, inappropriate healing, a resection of bone, or a procedure involving cutting or segmentation of bone in order to change its size, shape, or contour, the method comprising:
- a) preparing an adhesive composition comprising:
- (i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
- (ii) an aqueous medium;
- (iii) citric acid or malonic acid;
- (iv) calcium citrate;
- (v) phosphoserine;
- wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa
- and
- b) placing the composition into said gap or discontinuity;
- wherein the composition hardens and/or cures in less than about 30 minutes.
A method of repairing a defect in a tooth, the method comprising:
- a) preparing an adhesive composition comprising:
- (i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
- (ii) an aqueous medium;
- (iii) citric acid or malonic acid;
- (iv) calcium citrate;
- (v) phosphoserine;
- wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa;
- and
- b) placing the composition into or onto said tooth;
- wherein the composition hardens and/or cures in less than about 30 minutes.
Dependencies are inferred from the claim text.