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US 11,246,930 B2Granted
Reoviruses having modified sequences
AssigneeOncolytics Biotech Inc.
InventorMatthew C. Coffey
Life of this patent
Estimating the term…
Abstract
The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.
Claims14
A method of making an improved reovirus, comprising the steps of:
- modifying the nucleic acid sequence of said reovirus, and
- selecting one or more improved reoviruses, wherein the improved reovirus comprises a lambda-3 polypeptide having an amino acid modification which is a Leu at residue 979, an Arg at residue 1045 or a combination thereof, numbered relative to SEQ ID NO:23 (GenBank Accession no. M24734.1).
Dependencies are inferred from the claim text.