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US 11,246,844 B2Granted
Methods for inhibiting conversion of choline to trimethylamine (TMA)
AssigneesThe Procter & Gamble Company, The Cleveland Clinic Foundation
InventorsStanley Leon Hazen, Jose Carlos Garcia-Garcia, George Franklin Gerberick, John August Wos, Xiaodong Gu, Michael Reilly, Mark Robert Sivik, Jodie Michelle Reed, David Blair Cody
Life of this patent
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Abstract
A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I):
Claims3
A method of inhibiting the conversion of choline to trimethylamine (TMA) and reducing TMAO level in an individual comprising administering to the individual a composition comprising a compound selected from the group consisting of:
- N-(2,2-dimethoxyethyl)-N,N-dimethylprop-2-yn-1-aminium, N-(2,2-dihydroxyethyl)-N,N-dimethylprop-2-yn-1-aminium, N-(2-hydroxyethyl)-N,N-dimethylbut-3-yn-1-aminium, N-(2,2-diethoxyethyl)-N,N-dimethylprop-2-yn-1-aminium, 4-hydroxy-1-methyl-1-(prop-2-yn-1-yl)piperidin-1-ium, 2-cyano-N,N-dimethyl-N-(prop-2-yn-1-yl)prop-2-en-1-aminium, trimethyl(prop-2-ynyl)ammonium, allyl-(cyanomethyl)-dimethyl-ammonium, or N-(2-hydroxyethyl)-N,N-dimethylprop-2-yn-1-aminium, and a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.