Compositions and methods for inhibiting biofilm deposition and production
AssigneeThe Trustees of the University of Pennsylvania
InventorsHyun Koo, Henry Daniell
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Abstract
The invention provides a method for combating biofilm, said method comprising contacting a biofilm with a composition comprising an effective amount of antimicrobial peptide biofilm enzyme combinations, preferably in the form of a fusion protein. The biofilm may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides a composition for use in the treatment or prevention of a biofilm in a subject, particularly in the oral cavity.
Claims26
A multi-component composition comprising freeze dried plant leaves harboring a nucleic acid encoding at least one antimicrobial peptide (AMP) operably linked to a nucleic acid encoding a mutanase enzyme of SEQ ID NO:
- 1 for production of an AMP-mutanase fusion protein, said AMP and mutanase enzyme acting synergistically to degrade biofilm structures and inhibit biofilm deposition, said composition comprising a biologically acceptable carrier for delivery of said composition.
Dependencies are inferred from the claim text.