Back to results
US 11,243,207 B2Granted
Assessing and treating cancer
AssigneeMayo Foundation for Medical Education and Research
InventorsJohn A. Copland, III, Laura Ann Marlow
Life of this patent
Estimating the term…
Abstract
This document relates to methods and materials for identifying and/or treating mammals having cancer (e.g., a SCD1-associated cancer). For example, methods and materials for using one or more stearoyl CoA desaturase 1 (SCD1) polypeptide inhibitors to treat a mammal having cancer (e.g., a SCD1-associated cancer) are provided.
Claims14
A method for identifying and treating a mammal having a cancer exhibiting stearoyl-Coenzyme A desaturase 1 (SCD1) polypeptide expression that is responsive to treatment with a SCD1 polypeptide inhibitor, said method comprising:
- detecting an elevated level of cMyc polypeptides within a biological sample of cancer from said mammal, thereby identifying said cancer as being responsive to treatment with said SCD1 polypeptide inhibitor, and
- administering said SCD1 polypeptide inhibitor to said mammal, wherein said SCD1 polypeptide inhibitor is a compound having Formula (II) or Formula (IIa):
- or pharmaceutically acceptable salt thereof;
- wherein:
- R1 is halo;
- X is (C═O)NR4—;
- Y is
- and
- R2, R3, and R4 are each independently H or an unsubstituted C1-6alkyl.
6 more elements
Dependencies are inferred from the claim text.