Neurotransmitters and methods of making the same
AssigneePurissima, Inc.
InventorsGeorge Rudenko, Robert Evans
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Abstract
In an aspect, the disclosure provides methods for making neurotransmitters in a host organism. The neurotransmitters can be cannabinoids and derivatives of cannabinoids. The host cells can be microalgae, fungi or other host cells. In a related aspect, the disclosure provides host cells engineered to have biochemical pathways for making neurotransmitters such as cannabinoids.
Claims20
A Prototheca moriformis host cell comprising a first nucleic acid encoding a hexanoyl-CoA synthase, a second nucleic acid encoding a 3,5,7-trioxododecanoyl-CoA synthase, a third nucleic acid encoding an olivetolic acid cyclase (or 3,5,7-trioxododecanoyl-CoA CoA-lyase), and a fourth nucleic acid encoding a geranyl-diphosphate:olivetolate geranyltransferase, wherein the first nucleic acid is operably linked to a control region, wherein the second nucleic acid is operably linked to a control region, wherein the third nucleic acid is operably linked to a control region, and wherein the fourth nucleic acid is operably linked to a control region.
Dependencies are inferred from the claim text.