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US 11,242,401 B2Granted
Monoclonal antibody and a method of use for the treatment of lupus
AssigneeBiocon Limited
InventorsPradip Nair, Ravindra Belavinakodige Sadashivarao, Ramakrishnan Melarkode
Life of this patent
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Abstract
The present invention relates to compositions and methods useful for the treatment of lupus using a humanized IgG1 anti-CD6 monoclonal antibody (T1h) that binds to the SRCR domain 1 (D1) of CD6 without blocking the interaction of CD6 with the CD6 ligand Activated Leukocyte Cell Adhesion Molecule (ALCAM).
Claims7
A method for treating lupus nephritis in a subject in need thereof comprising administering an anti-CD6 monoclonal antibody that comprises amino acid sequences of SEQ ID NO:
- 1 and SEQ ID NO:
- 2, and wherein the anti-CD6 monoclonal antibody is in a therapeutically effective amount to reduce the symptoms of lupus nephritis in the treated subject.
Dependencies are inferred from the claim text.