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US 11,241,014 B2Granted
Antimicrobial coatings and methods of making and using thereof
AssigneeGeorgia Tech Research Corporation
InventorsM. G. Finn, Jennifer Marie Beveridge, Allison Geoghan Aioub, Zhishuai Geng
Life of this patent
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Abstract
Disclosed are antimicrobial articles and surfaces, as well as methods of making such articles and surfaces.
Claims18
A process for rendering a polyvinyl chloride surface antimicrobial, the process comprising:
- (a) flowing an aqueous solution comprising an azidation reagent and a phase transfer catalyst across the polyvinyl chloride surface to form an azide-substituted polyvinyl chloride;
- and
- (b) contacting the azide-substituted polyvinyl chloride with an antimicrobial agent comprising an alkyne moiety under conditions effective to covalently bond the antimicrobial agent to the polyvinyl chloride surface.
A process for rendering a polyvinyl chloride surface antimicrobial, the process comprising:
- (a) contacting the polyvinyl chloride with an azidation reagent in the presence of a phase transfer catalyst to form an azide-substituted polyvinyl chloride;
- and
- (b) contacting the azide-substituted polyvinyl chloride with an antimicrobial agent comprising an alkyne moiety under conditions effective to covalently bond the antimicrobial agent to the polyvinyl chloride surface;
- wherein the wherein the antimicrobial agent comprises a polycationic polymer defined by Formula I below
- wherein
- Z represents, individually for each occurrence, S, Se, or NR3;
- A represents, individually for each occurrence, a heterocyclic ring comprising a cationic nitrogen center;
- X represents, individually for each occurrence, an anion;
- Y is absent, or represents, individually for each occurrence, a linking group;
- R1 is absent, or represents, individually for each occurrence, halogen, hydroxy, amino, cyano, azido, hydrazone, alkyl, alkenyl, alkynyl, alkoxy, aryl, heteroaryl, alkylaryl, alkylheteroaryl, cycloalkyl alkylcycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, peptidyl, polyamino, or polyalkyleneoxy;
- R2 is absent, or represents, individually for each occurrence, alkyl, alkenyl, alkynyl, alkoxy, aryl, heteroaryl, alkylaryl, alkylheteroaryl, cycloalkyl alkylcycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, peptidyl, polyamino, or polyalkyleneoxy;
- R3 represents, individually for each occurrence, alkyl, alkenyl, alkynyl, alkoxy, aryl, heteroaryl, alkylaryl, alkylheteroaryl, cycloalkyl alkylcycloalkyl, heterocycloalkyl, alkylheterocycloalkyl, peptidyl, polyamino, or polyalkyleneoxy;
- and
- n is an integer from 2 to 400,
- wherein at least one of R1, R2, or R3 comprises an alkynyl group.
12 more elements
Dependencies are inferred from the claim text.