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US 11,237,180 B2Granted
Methods and apparatus for bead manipulation in a tip of a liquid handler
AssigneeAndrew Alliance S.A.
InventorGiorgio Horak
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Abstract
The present invention is directed towards an apparatus and methods for a precise, fast and easy to use manipulation of beads. This method is particularly useful to carry out separation between the beads and the remaining supernants present in the fluid, maximizing the collection and purification efficiencies in tips for liquid handling.
Claims12
A method for separating beads, comprising:
- providing a liquid containing beads suspended into a volume, wherein at least some beads have magnetic properties;
- applying a magnetic field to at least a portion of the volume;
- varying the magnetic field applied onto the volume over time, wherein one or more magnetic field profiles of the magnetic field provide an optimized gradient of the magnetic field along a vertical axis of the volume;
- and
- separating the magnetic beads from the liquid into a bead cluster by action of the optimized gradient of the magnetic field.
2 more elements
Dependencies are inferred from the claim text.