Methods for identifying modulators of GPR92
AssigneeMars, Incorporated
InventorsScott Joseph McGrane, Matthew Ronald Gibbs, Richard Masten Fine, Boris Klebansky
Life of this patent
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Abstract
The present disclosure provides methods for identifying compounds that modulate the activity and/or expression of GPR92, wherein said compounds can be incorporated into flavor compositions that can be used to modify the taste and/or palatability of pet food products. In certain non-limiting embodiments, the present disclosure provides a method for identifying a composition that modulates the activity of a GPR92 receptor comprising (a) contacting a test agent with a GPR92 receptor, (b) determining the activity of the GPR92 receptor, and (c) selecting as the composition, a test agent that increases the activity of the GPR92 receptor.
Claims18
A method for identifying a composition that modulates the activity of a GPR92 receptor comprising:
- (a) contacting a test agent with a GPR92 receptor,
- (b) determining the activity of the GPR92 receptor, and
- (c) selecting as the composition, a test agent that increases the activity of the GPR92 receptor,
- wherein the GPR92 receptor is selected from the group consisting of a feline GPR92 receptor comprising the amino acid sequence set forth in SEQ ID NO:
- 4 and a canine GPR92 receptor comprising the amino acid sequence set forth in SEQ ID NO:
- 5.
A method for identifying a composition that modulates the activity of a GPR92 receptor comprising:
- (a) contacting a test agent with a GPR92 receptor,
- (b) detecting an interaction between the test agent and one or more amino acids in a 7 transmembrane domain (7TM) of the GPR92 receptor, and
- (c) selecting as the composition, a test agent that interacts with one or more of the amino acids,
- wherein the GPR92 receptor is selected from the group consisting of a feline GPR92 receptor comprising the amino acid sequence set forth in SEQ ID NO:
- 4 and a canine GPR92 receptor comprising the amino acid sequence set forth in SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.