Method for detecting HIV-1-specific antibodies using clade C env polypeptides
AssigneeViravaxx AG
InventorsRudolf Valenta, Daniela Gallerano, Elopy N. Sibanda
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Abstract
The present invention relates to a method for detecting and/or quantifying human immunodeficiency virus (HIV) specific antibodies in a sample of a subject comprising the step of determining the presence and/or amount of antibodies binding to a) a peptide consisting of the amino acid sequence AIVCTRPNNNTRKSIRIGPGQVFYT (SEQ. ID No. 1), or b) a homolog having at least 70% identity with a peptide of a), or c) a fragment of a peptide of a) or b) consisting of 15 to 24 amino acid residues in said sample.
Claims9
A method for detecting or quantifying human immunodeficiency virus type 1 (HIV-1) specific antibodies in a sample of a subject, the method comprising the steps of:
- a) immobilizing one or more peptides or polypeptides on a solid support, wherein said peptides consist of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-5;
- b) contacting the solid support with the sample under conditions that permit antigen-antibody binding;
- and,
- c) detecting antigen-antibody binding through radioimmune assay (RIA), enzyme-linked immunosorbent assay (ELISA), Western blot assay, dot blot assay, bead assay, or peptide array assay.
Dependencies are inferred from the claim text.