US 11,236,520 B2Granted

Customizable facility

AssigneeLonza Ltd.

InventorsJonathan Fortin, Lesley Wood, Stefan Widmer, Sandra Carbonneau, Alexander Zahiri

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Abstract

A customizable facility for manufacturing at least one product has at least one modular unit in communication with at least one central unit configured to provide utilities to the at least one modular unit. In some embodiments, the central unit(s) and modular unit(s) are positioned at least partially within a shell. Each modular unit can be a fermentation unit, a pre-viral unit, a post-viral unit, a utility space, a warehouse, a media buffer facility, an office, a personnel unit, or another unit. The modular units can be arranged to maximize a number of modular units within the shell while minimizing a footprint of the shell. A method of assembling a facility for manufacturing at least one product includes providing at least one central unit and providing at least one modular unit in communication with the central unit(s) such that utilities are provided by the central unit(s) to the modular unit(s).

Claims27

Dependent claims

A customizable facility for manufacturing at least one pharmaceutical product, the customizable facility comprising:

at least one central unit positioned on a ground surface floor of the customizable facility;
and
a plurality of modular units in communication with the at least one central unit such that the at least one central unit provides shared utilities to each modular unit the plurality of modular units including
a first set of modular units located at least one floor vertically above the at least one central unit for manufacturing a first pharmaceutical product, the first set of modular units having a first modular unit that is a fermentation unit, a second modular unit that is a pre-viral unit, a third modular unit that is a post-viral unit, a fourth modular unit that is a fill-finish unit, a fifth modular unit that is a dosage formulation unit, and a sixth modular unit that is a packaging unit, and
a second set of modular units located at least one floor vertically above the at least one central unit for manufacturing a second pharmaceutical product, the second set of modular units having a seventh modular unit that is a fermentation unit, an eighth modular unit that is a pre-viral unit, a ninth modular unit that is a post-viral unit, a tenth modular unit that is a fill-finish unit, an eleventh modular unit that is a dosage formulation unit, and a twelfth modular unit that is a packaging unit;
and
a shell, wherein the at least one central unit is positioned at least partially within the shell and the plurality of modular units are positioned at least partially within the shell, and the shell is supported on footings secured in the ground surface.

4 more elements

A method of assembling a facility for manufacturing at least one pharmaceutical product, the method comprising:

providing at least one central unit positioned on a ground surface floor of the customizable facility;
and
providing a plurality of modular units in communication with the at least one central unit such that the at least one central unit provides shared utilities to each modular unit, the plurality of modular units including
a first set of modular units located at least one floor vertically above the at least one central unit for manufacturing a first pharmaceutical product, the first set of modular units having a first modular unit that is a fermentation unit, a second modular unit that is a pre-viral unit, a third modular unit that is a post-viral unit, a fourth modular unit that is a fill-finish unit, a fifth modular unit that is a dosage formulation unit, and a sixth modular unit that is a packaging unit, and
a second set of modular units located at least one floor vertically above the at least one central unit for manufacturing a second pharmaceutical product, the second set of modular units having a seventh modular unit that is a fermentation unit, an eighth modular unit that is a pre-viral unit, a ninth modular unit that is a post-viral unit, a tenth modular unit that is a fill-finish unit, an eleventh modular unit that is a dosage formulation unit, and a twelfth modular unit that is a packaging unit;
and
a shell, wherein the at least one central unit is positioned at least partially within the shell and the plurality of modular units are positioned at least partially within the shell, and the shell is supported on footings secured in the ground surface.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/455,836Filed 10 Mar 2017 · us provisional application
Priority: 10 Mar 2016
Published: US 2017/0260763 A114 Sep 2017
Granted: 1 Feb 2022
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

E04H 1/005
Buildings or groups of buildings for dwelling or office purposes; General layout, e.g. modular co-ordination or staggered storeys: modulation…
C12M 37/00
Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
E04H 5/00
Buildings or groups of buildings for industrial or agricultural purposes
E04H 5/02
Buildings or groups of buildings for industrial or agricultural purposes: buildings or groups of buildings for industrial purposes, e.g. for…