Method for screening drug and therapeutic targets used for treating Alzheimer's disease
AssigneeJiangsu Nuo-Beta Pharmaceutical Technology Co. Ltd.
InventorsFude Huang, Xiao Zhang, Wenan Wang, Haiyan Liu
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Abstract
Disclosed is the use of genetic means or a related inhibitor to inhibit and down-regulate the amount of PI4KIIIα protein, RBO/EFR3/EFR3A/EFR3B membrane proteins, TTC7 protein and membrane protein complexes formed by said proteins, or related enzyme activity to promote Aβ secretion by neuronal cells, reduce Aβ accumulation within neurons, and thereby reduce AD model fruit fly and mouse nerve dysfunction.
Claims7
A method for screening a medicine or a therapeutic target for treating Alzheimer's disease, the method comprising screening the medicine or the therapeutic target for the ability to increase Aβ secretion from cultured cells or Drosophila tissue, and selecting the medicine or therapeutic target that increases Aβ secretion from the cells or Drosophila tissue as a candidate to treat Alzheimer's disease.
Dependencies are inferred from the claim text.