Adenovirus and uses thereof
AssigneeJanssen Vaccines & Prevention B.V.
InventorsTaco Gilles Uil, Soumitra Roy, Selina Khan, Jerôme H. H. V. Custers
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Abstract
Provided herein are adenoviral nucleic acid sequences and adenoviral vectors comprising said nucleic acid sequences. The provided adenoviral vectors can be used to induce a protective immune response in a subject.
Claims17
An isolated nucleic acid sequence encoding a hexon polypeptide or a functional derivative thereof comprising a hexon hypervariable regions-encompassing polypeptide having the amino acid sequence of SEQ ID NO:1 or an amino acid sequence which is at least 95% identical over its entire length to the amino acid sequence of SEQ ID NO:1.
An isolated nucleic acid sequence encoding a fiber polypeptide comprising at least one selected from the group consisting of:
- (1) a fiber knob polypeptide sequence comprising the amino acid sequence of SEQ ID NO:10;
- (2) a fiber shaft polypeptide sequence comprising the amino acid sequence of SEQ ID NO:11, and (3) a fiber tail polypeptide sequence comprising the amino acid sequence of SEQ ID NO:12.
Dependencies are inferred from the claim text.