Secretory immunoglobulin a (sIgA)-binding nucleic acid molecule, sIgA analysis sensor, and sIgA analysis method
AssigneesNEC Solution Innovators, Ltd., National University Corporation Gunma University
InventorsHirotaka Minagawa, Katsunori Horii, Jou Akitomi, Naoto Kaneko, Iwao Waga, Masayasu Kuwahara
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Abstract
The present invention provides a novel molecule that can be used for detection of sIgA. The sIgA-binding nucleic acid molecule of the present invention is characterized in that it binds to secretory immunoglobulin A (sIgA) with a dissociation constant of 37.7 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 12 or a partial sequence thereof, for example. According to the sIgA-binding nucleic acid molecule of the present invention, it is possible to detect sIgA in saliva.
Claims19
A secretory immunoglobulin A (sIgA)-binding nucleic acid molecule that binds to sIgA with a dissociation constant of 37.7 nM or less,
- wherein the sIgA-binding nucleic acid molecule comprises the following polynucleotide (a) or (c):
- (a) a polynucleotide consisting of any of sequences of SEQ ID NOs:
- 1 to 12;
- and
- (c) a polynucleotide that consists of a sequence having at least 90% sequence identity to any of the sequences of the polynucleotide (a) and binds to the sIgA.
A secretory immunoglobulin A (sIgA)-binding nucleic acid molecule that binds to sIgA with a dissociation constant of 37.7 nM or less,
- wherein the sIgA-binding nucleic acid molecule comprises the following polynucleotide (a) or (c):
- (a) a following polynucleotide (a1), (a2), (a3) or (a4):
- (a1) a polynucleotide consisting of any of sequences of SEQ ID NOs:
- 13, 14, and 15;
- (a2) a polynucleotide consisting of either of sequences of SEQ ID NOs:
- 16 and 17;
- (a3) a polynucleotide consisting of either of sequences of SEQ ID NOs:
- 18 and 19;
- and
- (a4) a polynucleotide consisting of either of sequences of SEQ ID NOs:
- 20 and 21;
- (c) a polynucleotide that consists of a sequence having at least 90% sequence identity to any of the sequences of the polynucleotide (a) and binds to the sIgA.
Dependencies are inferred from the claim text.