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AssigneeThe Research Foundation for The State University of New York
InventorsJingfang Ju, Andrew Fesler, Younghwa Song, Jun Chung
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The present disclosure provides nucleic acid compositions that incorporate one or more halouracil molecules. More specifically, the present disclosure reveals that the replacement of uracil nucleotides within a microRNA nucleotide sequence with a 5-halouracil increases the ability of the micro-RNA to inhibit cancer progression and tumorigenesis. As such, the present disclosure provides various nucleic acid (e.g., microRNA) compositions having 5-halouracil molecules incorporated in their nucleic acid sequences and methods for using the same. The present disclosure further provides pharmaceutical compositions comprising the modified nucleic acid compositions, and methods for treating cancers using the same.
A method for treating breast cancer comprising administering to a subject an effective amount of a modified microRNA having a nucleotide sequence CGACGGCAUFAUFACACUFACAGUFG [SEQ ID NO. 32], wherein said subject has been diagnosed with breast cancer, and wherein progression of said breast cancer is inhibited by the administration of the modified microRNA nucleic acid composition, wherein said breast cancer is triple negative breast cancer.
A method for treating breast cancer comprising administering to a subject an effective amount of a modified microRNA consisting of a nucleotide sequence CGACGGCAUFAUFACACUFACAGUFG [SEQ ID NO. 32], wherein said subject has been diagnosed with breast cancer, and wherein progression of said breast cancer is inhibited by the administration of the modified microRNA nucleic acid composition.
Dependencies are inferred from the claim text.