Antisense oligonucleotides for the treatment of Stargardt disease

An antisense oligonucleotide for redirecting splicing that is:

• complementary or substantially complementary to a polynucleotide with a nucleotide sequence consisting of SEQ ID NO:
• 10, 30, or a part thereof;
• and wherein the antisense oligonucleotide comprises a 2′-O alkyl phosphorothioate antisense oligonucleotide, such as 2′-O-methyl modified ribose (RNA), 2′-O-ethyl modified ribose, 2′-O-propyl modified ribose, and/or substituted derivatives of these modifications such as halogenated derivatives.