MicroRNAs for cardiac regeneration through induction of cardiac myocyte proliferation
AssigneeKing's College London
InventorsMauro Giacca, Serena Zacchigna, Miguel Luis Cunha Mano, Ana Sofia Bregieiro Eulalio
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Abstract
The present invention discloses a set of human microRNAs, or a primary transcript for such microRNAs, or a precursor of such microRNAs, or a mimic of such microRNAs or a combination thereof, and their use as medicaments for inducing proliferation of cardiomyocytes for the prevention and treatment of heart diseases associated with a loss of cardiomyocytes. The invention also relates to a method for screening microRNAs and biological and therapeutically active compounds for their ability to increase proliferation of cardiomyocytes.
Claims2
A human cardiomyocyte comprising a vector, said vector comprising at least a microRNA and/or a DNA coding for at least said microRNA and/or a DNA coding for at least a primary transcript or a precursor for said microRNA, or a combination thereof, wherein said microRNA, or combination of microRNAs, is selected from the group consisting of:
- (SEQ ID NO:
- 29)
- UAAUUUUAUGUAUAAGCUAGU,
- (SEQ ID NO:
- 14)
- ACAGUAGUCUGCACAUUGGUUA, and
- (SEQ ID NO:
- 1)
- ACUGCCCUAAGUGCUCCUUCUGG.
Dependencies are inferred from the claim text.