Human monoclonal antibodies specific for FLT3 and uses thereof
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsDimiter S. Dimitrov, Weizao Chen, Terry J. Fry, Christopher Chien, Haiying Qin
Life of this patent
Estimating the term…
Abstract
Human monoclonal antibodies that specifically bind Fms-like tyrosine kinase 3 (FLT3) are described. Chimeric antigen receptors (CARs) and other antibody conjugates that include the FLT3-specific monoclonal antibodies are also described. Methods for the diagnosis and treatment of FLT3-associated cancer, such as acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML), are further described.
Claims26
An isolated monoclonal antibody that binds Fms-like tyrosine kinase 3 (FLT3), or an antigen-binding fragment thereof, comprising:
- a variable heavy (VH) domain and a variable light (VL) domain, wherein the VH domain of the antibody comprises the complementarity determining region (CDR) sequences of SEQ ID NO:
- 1 and the VL domain of the antibody comprises the CDR sequences of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.