Monoclonal antibody to PD-L1

A monoclonal antibody or antigen binding fragment thereof that specifically binds to PD-L1 comprising:

• a) a heavy chain variable domain comprising the amino acid sequences corresponding to SEQ ID NO:
• 1, 2 and 3;
• a light chain variable domain comprising the amino acid sequences corresponding to SEQ ID NO:
• 5, 6 and 7;
• or
• b) a variant of a) comprising a combination of amino acid substitutions selected from the following group:
• i) the first amino acid of SEQ ID NO:
• 1 is A, the second amino acid of SEQ ID NO:
• 1 is N, the seventh amino acid of SEQ ID NO:
• 3 is T, the fourth amino acid of SEQ ID NO:
• 7 is V, the sixth amino acid of SEQ ID NO:
• 7 is T and the eighth amino acid of SEQ ID NO:
• 7 is S;
• ii) the first amino acid of SEQ ID NO:
• 1 is N, the fourth amino acid of SEQ ID NO:
• 3 is P, the seventh amino acid of SEQ ID NO:
• 3 is T, the fourth amino acid of SEQ ID NO:
• 7 is T, the sixth amino acid of SEQ ID NO:
• 7 is T and the eighth amino acid of SEQ ID NO:
• 7 is S;
• iii) the first amino acid of SEQ ID NO:
• 1 is N, the second amino acid of SEQ ID NO:
• 1 is N, the seventh amino acid of SEQ ID NO:
• 3 is T, the fourth amino acid of SEQ ID NO:
• 7 is T, the sixth amino acid of SEQ ID NO:
• 7 is T and the eighth amino acid of SEQ ID NO:
• 7 is S;
• iv) the first amino acid of SEQ ID NO:
• 1 is A, the second amino acid of SEQ ID NO:
• 1 is N, the fourth amino acid of SEQ ID NO:
• 3 is P, the seventh amino acid of SEQ ID NO:
• 3 is T, the fourth amino acid of SEQ ID NO:
• 7 is V, the sixth amino acid of SEQ ID NO:
• 7 is T and the eighth amino acid of SEQ ID NO:
• 7 is S;
• v) the first amino acid of SEQ ID NO:
• 1 is K, the second amino acid of SEQ ID NO:
• 1 is S, the fifth amino acid of SEQ ID NO:
• 1 is I, the fourth amino acid of SEQ ID NO:
• 3 is M, the seventh amino acid of SEQ ID NO:
• 3 is A, the fourth amino acid of SEQ ID NO:
• 7 is Y, the sixth amino acid of SEQ ID NO:
• 7 is T and the eighth amino acid of SEQ ID NO:
• 7 is S;
• vi) the first amino acid of SEQ ID NO:
• 1 is S, the second amino acid of SEQ ID NO:
• 1 is T, the fourth amino acid of SEQ ID NO:
• 3 is V, the seventh amino acid of SEQ ID NO:
• 3 is I, the fourth amino acid of SEQ ID NO:
• 7 is T, the sixth amino acid of SEQ ID NO:
• 7 is T and the eighth amino acid of SEQ ID NO:
• 7 is S;
• vii) the first amino acid of SEQ ID NO:
• 1 is A, the fourth amino acid of SEQ ID NO:
• 3 is P, the fifth amino acid of SEQ ID NO:
• 3 is S, the seventh amino acid of SEQ ID NO:
• 3 is I, the fourth amino acid of SEQ ID NO:
• 7 is E, the sixth amino acid of SEQ ID NO:
• 7 is T and the eighth amino acid of SEQ ID NO:
• 7 is S;
• and
• viii) the first amino acid of SEQ ID NO:
• 1 is N, the second amino acid of SEQ ID NO:
• 1 is N, the seventh amino acid of SEQ ID NO:
• 3 is T, the fourth amino acid of SEQ ID NO:
• 7 is T, the sixth amino acid of SEQ ID NO:
• 7 is T and the eighth amino acid of SEQ ID NO:
• 7 is S.