Chimeric antigen receptors targeting CD-19

A method of treating or preventing a B-cell malignancy in a subject,

• the method comprising administering to the subject an effective amount of one or more T cells or NK cells comprising a vector,
• wherein the vector comprises a nucleic acid encoding a chimeric antigen receptor (CAR) directed against CD19, wherein the CAR comprises an amino acid sequence of SEQ ID NO:
• 1, SEQ ID NO:
• 2, SEQ ID NO:
• 3, SEQ ID NO:
• 4, SEQ ID NO:
• 5, SEQ ID NO:
• 6, SEQ ID NO:
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• 9, SEQ ID NO:
• 10, SEQ ID NO:
• 11, SEQ ID NO:
• 12, or SEQ ID NO:
• 13, and
• wherein the B-cell malignancy is leukemia, lymphoma, or multiple myeloma.