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US 11,236,158 B2Granted
Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications
AssigneeSwedish Orphan Biovitrum AG
InventorsCristina De Min, Walter Ferlin, Fabrizio De Benedetti
Life of this patent
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Abstract
The disclosure relates generally to methods compositions and dosing regimens for treating, preventing and/or delaying the onset or progression of, or alleviating a symptom associated with elevated IFN-γ levels.
Claims6
A method of diagnosing and treating graft failure in a patient who has received an allogeneic hematopoietic stem cell transplant comprising:
- a. detecting if Chemokine (C-X-C motif) Ligand 9 (CXCL9) is present in a blood sample obtained from the patient;
- b. diagnosing the patient with graft failure when CXCL9 is elevated in comparison to a control sample;
- and
- c. administering a Interferon Gamma (IFNγ) antagonist to the patient.
1 more element
Dependencies are inferred from the claim text.