Antibodies to pyroglutamate amyloid-β and uses thereof
AssigneeJanssen Pharmaceutica NV
InventorsBianca Van Broeck, Marc Mercken, Wilson Edwards, Sanjaya Singh, Jinquan Luo, Sherry La Porte, Rajkumar Ganesan, Chichi Huang
Life of this patent
Estimating the term…
Abstract
The invention provides antibodies or antigen binding fragments thereof that bind to 3pE Aβ and methods of making and using the antibodies or antigen binding fragments thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other β-amyloid-related diseases.
Claims23
An isolated monoclonal antibody or antigen-binding fragment thereof comprising a heavy complementarity determining region 1 (HCDR1), HCDR2, HCDR3, and a light chain complementarity determining region 1 (LCDR1), LCDR2, and LCDR3, having the polypeptide sequences of:
- a. SEQ ID NOs:
- 1, 2, 3, 4, 5, and 6, respectively;
- b. SEQ ID NOs:
- 1, 7, 3, 4, 5, and 6, respectively;
- c. SEQ ID NOs:
- 1, 7, 3, 8, 5, and 6, respectively;
- d. SEQ ID NOs:
- 1, 2, 3, 8, 5, and 6, respectively;
- e. SEQ ID NOs:
- 56, 57, 3, 8, 5, and 6, respectively;
- f. SEQ ID NOs:
- 56, 57, 3, 4, 5, and 6, respectively;
- g. SEQ ID NOs:
- 56, 58, 3, 4, 5, and 6, respectively;
- h. SEQ ID NOs:
- 56, 7, 3, 8, 5, and 6, respectively;
- i. SEQ ID NOs:
- 1, 57, 3, 8, 5, and 6, respectively;
- j. SEQ ID NOs:
- 56, 7, 3, 4, 5, and 6, respectively;
- k. SEQ ID NOs:
- 1, 57, 3, 4, 5, and 6, respectively;
- l. SEQ ID NOs:
- 1, 58, 3, 4, 5, and 6, respectively;
- or
- m. SEQ ID NOs:
- 56, 2, 3, 4, 5, and 6, respectively;
- wherein the antibody or antigen-binding fragment thereof specifically binds amyloid-β peptide having pyroglutamate at the third residue (3pE Aβ).
An isolated monoclonal antibody comprising:
- a. a heavy chain amino acid sequence comprising SEQ ID NO:37 and a light chain amino acid sequence comprising SEQ ID NO:38;
- b. a heavy chain amino acid sequence comprising SEQ ID NO:39 and a light chain amino acid sequence comprising SEQ ID NO:38;
- c. a heavy chain amino acid sequence comprising SEQ ID NO:37 and a light chain amino acid sequence comprising SEQ ID NO:52;
- d. a heavy chain amino acid sequence comprising SEQ ID NO:39 and a light chain amino acid sequence comprising SEQ ID NO:
- 52;
- e. a heavy chain amino acid sequence comprising SEQ ID NO:37 and a light chain amino acid sequence comprising SEQ ID NO:54;
- or
- f. a heavy chain amino acid sequence comprising SEQ ID NO:39 and a light chain amino acid sequence comprising SEQ ID NO:54.
Dependencies are inferred from the claim text.