Methods and compositions for the inhibition of TRPV4
AssigneeChildren's Medical Center Corporation
InventorsDonald E. Ingber, Mariko Kobayashi
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Abstract
TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number of pathological conditions, e.g., edema, inflammation, hypertension, and/or hyperalgesia. Described herein are methods and compositions relating to inhibition of mechanically-induced TRPV4 activation, e.g., for the treatment of pulmonary edema, edema, inflammation, hypertension, and/or hyperalgesia.
Claims8
A method of inhibiting mechanically-dependent activation of Transient Receptor Potential Vanilloid 4 (TRPV4), the method comprising contacting a mammalian cell with a nucleic acid encoding a polypeptide:
- comprising a sequence with at least 95% identity to the sequence of SEQ ID NO:
- 1;
- comprising no more than 200 amino acids;
- and
- capable of inhibiting binding of TRPV4 or integrin to Cluster of Differentiation 98 (CD98).
Dependencies are inferred from the claim text.