Extracellular vesicle comprising a fusion protein having Fc binding capacity
AssigneeEvox Therapeutics Ltd
InventorsOscar Wiklander, André Görgens, Dhanu Gupta
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Abstract
The present invention pertains to extracellular vesicle (EV) therapeutics, wherein the EVs are coated with proteins containing Fc domains (such as antibodies) for i.a. targeting and therapeutic applications. The coating of EVs is achieved through inventive protein engineering of EV polypeptides. The present invention thus relates to methods for coating of EVs, EVs per se, as well as pharmaceutical compositions and medical applications of such EVs coated with Fc containing proteins.
Claims12
An exosome comprising at least one fusion protein, wherein the at least one fusion protein comprises at least one Fc binding polypeptide displayed on the outer surface of the exosome, wherein the at least one Fc binding polypeptide is fused to at least one human exosomal polypeptide;
- wherein the at least one Fc binding polypeptide is selected from the group consisting of Protein A, Protein G, Protein A/G, Protein L, Protein LG, Z domain, ZZ domain, and a combination thereof;
- and
- wherein the at least one human exosomal polypeptide is selected from the group consisting of CD9, CD63, CD81, Lamp2b, TFNR, and a combination thereof.
Dependencies are inferred from the claim text.