Divalent nucleobase compounds and uses therefor
AssigneeCarnegie Mellon University
InventorsDanith H. Ly, Suresh Kumar Gopalsamy, Arunava Manna
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Abstract
Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (γPNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
Claims20
A compound comprising a moiety of the formula:
- attached to a nucleic acid analogue, wherein each R1 is independently a protecting group or H, and X is CH or N.
A method comprising contacting a nucleic acid with a compound, wherein the compound comprises a moiety of the formula:
- attached to a nucleic acid analogue wherein each R1 is independently a protecting group or H, and X is CH or N.
A method of treating a condition, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound, wherein the compound comprises a moiety of the formula:
- attached to a nucleic acid analogue, wherein each R1 is independently a protecting group or H, and X is CH or N.
Dependencies are inferred from the claim text.