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US 11,236,129 B2Granted
IL-17A binding peptides and medical uses thereof
AssigneeDompé Farmaceutici S.P.A.
InventorsMarcello Allegretti, Andrea Aramini, Andrea Beccari, Marica Gemei, Flavio Mantelli
Life of this patent
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Abstract
The invention relates to IL-17A binding peptides, inhibitors of the interaction of IL-17A with the receptor IL-17RA, and to bioconjugates, dimers, pharmaceutical compositions and medical use thereof.
Claims16
A peptide that specifically inhibits IL-17A binding to ILRA, comprising the amino acid sequence of Formula (I), wherein Formula (I) comprises:
- (I)
- (SEQ ID NO:
- 258)
- X1-X2-X3-X4 X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15
- wherein in Formula (I):
- (a) X1 is I, V or L;
- X2 is H, M, R, K or E;
- X3 is V, F or I;
- X4 is T, Q, S, Y or N;
- X5 is I, F or V;
- X6 is P;
- X7 is A, Q, or L;
- X8 is D, E, or Q;
- X9 is L, W, F, V or I;
- X10 is W, Y or F;
- X11 is D, E or N;
- X12 is W or F;
- X13 is I, V, F or L;
- X14 is N, R, Q or E;
- X15 is K, R, H or E;
- with the proviso that said sequence is not IHVTIPADLWDWINK (SEQ ID NO:1);
- or
- (b) X1 is I or V,
- X2 is H, M or R,
- X3 is V or F;
- X4 is T or Q;
- X5 is I, F or V;
- X6 is P or G;
- X7 is A or Q;
- X8 is D or E;
- X9 is L;
- X10 is W or Y;
- X11 is D or E;
- X12 is W;
- X13 is I or V;
- X14 is N, R or E;
- X15 is K, R or E;
- with the proviso that said sequence is not IHVTIPADLWDWINK (SEQ ID NO:
- 1)
- or
- (c) X1 is I or V;
- X2 is H or M,
- X3 is V;
- X4 is T;
- X5 is I;
- X6 is P;
- X7 is A;
- X8 is D;
- X9 is L, W, F, V or I;
- X10 is W or Y;
- X11 is D or E;
- X12 is W;
- X13 is I or V;
- X14 is N, R or E;
- X15 is K, R or E;
- with the proviso that said sequence is not IHVTIPADLWDWINK (SEQ ID NO:
- 1), HVTIPADLWDWIN (SEQ ID NO:259), IHVTIPADLWDWI (SEQ ID NO:260) or IHVTIPADLWDW (SEQ ID NO:261).
54 more elements
Dependencies are inferred from the claim text.