Compounds and uses thereof for the modulation of hemoglobin

A compound of Formula (IIA):

• or a tautomer thereof, or a pharmaceutically acceptable salt of each thereof, wherein
• ring A is a 4-10 membered cycloalkyl or 4-10 membered heterocycle containing up to 5 ring heteroatoms, wherein the heterocycle is saturated or contains one double bond, and each heteroatom is independently selected from the group consisting of O, N, S, and oxidized forms of N and S;
• wherein the cycloalkyl and heterocycle are each optionally substituted with 1 to 5 substituents independently selected from halo and C1-C6 alkyl;
• ring B is a 6-membered heteroaryl having 1-2 nitrogen atoms, or an oxidized form thereof, wherein the heteroaryl is optionally substituted with 1-3 substituents independently selected from halo and C1-C6 alkyl;
• is a single or a double bond;
• R5 is hydrogen or C1-C6 alkyl, wherein the C1-C6 alkyl is optionally substituted with 1-5 halo;
• each R6 independently is halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkyl-S(O)—, or C1-C6 alkyl-S(O)2—, wherein the C1-C6 alkyl is optionally substituted with 1-5 halo;
• or a 4-10 membered cycloalkyl or heterocyclyl substituted with an R′R′N— moiety wherein each R′ is independently C1-C6 alkyl or hydrogen;
• and
• p is 0, 1, 2,or 3.