Bifunctional compounds

A compound of Formula (II):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is
• wherein R1 is optionally substituted with one or more RA;
• each n is independently an integer of 1, 2 or 3;
• each R2a and R2b is independently H, deuterium, halogen, or C1-C6 alkyl;
• each R3 is independently H, deuterium, C1-C6 alkyl,
• each RA is independently deuterium, hydroxyl, halogen, cyano, nitro, optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, optionally substituted amino, C1-C6 alkylamino, amino(C1-C6 alkyl), —(C═O)NR10aR10b, (C1-C6 alkoxy)C1-C6 alkyl, —O—(C1-C6 alkoxy)C1-C6 alkyl, or optionally substituted C3-C7 cycloalkyl;
• each of R4 and R6 is independently H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, optionally substituted C3-C7 cycloalkyl(C1-C3 alkyl), or optionally substituted C3-C7 cycloalkyl;
• each of R5a, R5b, and R5c is independently H or C1-C6 alkyl;
• each of R7a and R7b is independently H, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C6-C10 aryl, optionally substituted 5 to 10 membered heteroaryl, optionally substituted C7-C14 aralkyl, optionally substituted 3 to 10 membered heterocyclyl, or optionally substituted C3-C8 carbocyclyl;
• each of R8a and R8b is independently H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, or C3-C8 carbocyclyl;
• each of R9a and R9b is independently H, optionally substituted C1-C6 alkyl, optionally substituted C6-C10 aryl, optionally substituted C7-C14 aralkyl, or optionally substituted C3-C8 carbocyclyl;
• each R10a and R10b is independently H or C1-C6 alkyl;
• or R10a and R10b together with the nitrogen atom to which they are attached form an optionally substituted 5 or 6 membered heterocyclyl optionally substituted with one or more R11;
• each R11 is independently C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, (C1-C6 alkoxy)C1-C6 alkyl, —O—(C1-C6 alkoxy)C1-C6 alkyl, optionally substituted amino, halogen, or cyano;
• or two geminal R11 form oxo;
• Q is CH2 or C═O;
• L1 is a bond,
• wherein the asterisk * indicates the point of connection to X1;
• each of Z1a, Z1b Z1c, Z1d, Z1e, and Z1f is independently a bond or —(CRaRb)q1—;
• Z2 is —(CRcRd)q2—;
• Z3 is a bond, O or NR12g;
• each of Ra, Rb, Rc and Rd is independently H, halogen, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, or optionally substituted C3-C6 cycloalkyl;
• each q1 and q2 is independently an integer of 1, 2, or 3;
• each Xa and Xb is independently O or S;
• each Ring A is independently phenyl or a five to six membered heteroaryl, each optionally substituted with one or more R11;
• each of Y1, Y2, Y3, Y4, Y5 and Y6 is —NR12h—, —O—, or —S—;
• each R12a, R12b, R12c, R12d, R12e, R12f, R12g and R12h is independently H or C1-C6 alkyl;
• each of m1, m2, m3, m4, m5, m6, k1, k2, k3, k4, k5, k6, p1, p2, p3, p4, p5, and p6 is independently an integer of 0, 1, 2, or 3;
• L2 is a bond, —(CH2)1-6NH—, —(CH2)0-6—C(═O)—, or —(CH2)0-3—C(═O)NR13—;
• R13 is H or C1-C6 alkyl;
• X1 is C1-C15 alkylene or heteroalkylene;
• and
• Ring B is phenyl or a 6 membered heteroaryl, optionally substituted with one or more R11.