Fused pyrimidine compound or salt thereof
AssigneeTaiho Pharmaceutical Co., Ltd.
InventorsIsao Miyazaki, Tadashi Shimamura, Masanori Kato, Hidenori Fujita
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Abstract
The present invention provides a novel RET inhibitor comprising, as an active ingredient, a compound or a salt thereof that have not been known for their RET inhibitory activity, and also provides an agent for preventing or treating diseases (e.g., malignant tumors) that can be prevented or treated by RET inhibitory activity. The RET inhibitor comprises, as an active ingredient, a compound represented by Formula (I) below or a salts thereof: wherein A, R1 to R3, X, and n are as defined in the specification.
Claims8
A method for treating a malignant tumor, comprising administering an effective amount of a compound represented by Formula (I) below or a salt thereof to a mammal in need thereof:
- wherein A is pyrazolyl substituted with n-number of R′;
- R1 is
- halogen,
- cyano,
- substituted or unsubstituted C1-C6 alkyl,
- substituted or unsubstituted C3-C7 cycloalkyl,
- substituted or unsubstituted C6-C14 aromatic hydrocarbon, or
- a substituted or unsubstituted C3-C10 monocyclic or polycyclic saturated or unsaturated heterocyclic group containing 1 to 3 identical or different heteroatoms selected from nitrogen, oxygen, and sulfur;
- R2 is
- substituted or unsubstituted C1-C10 alkyl,
- substituted or unsubstituted C3-C7 cycloalkyl,
- substituted or unsubstituted C2-C6 alkenyl,
- substituted or unsubstituted C3-C7 cycloalkenyl,
- substituted or unsubstituted C4-C12 bridged cycloalkyl, substituted or unsubstituted C6-C14 aromatic hydrocarbon, or
- a substituted or unsubstituted C3-C10 monocyclic or polycyclic saturated or unsaturated heterocyclic group containing 1 to 3 identical or different heteroatoms selected from nitrogen, oxygen, and sulfur;
- X is N;
- and
- n is an integer of 0 to 3,
- wherein when n is 2 or 3, R1 may be identical or different from each other.
Dependencies are inferred from the claim text.