Protein kinase B inhibitors
AssigneeAstraZeneca AB
InventorsPaul David Johnson, Andrew Leach, Richard William Arthur Luke, Zbigniew Stanley Matusiak, Jeffrey James Morris
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Abstract
The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).
Claims10
A method of treating prostate cancer, comprising:
- administering to a person in need thereof a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- Y represents N;
- Z1-Z2 represents a group selected from C(R6)═CH;
- where
- R6 represents hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, difluoromethyl, trifluoromethyl or cyclopropyl;
- n is 0, 1 or 2;
- R1 represents C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy;
- C1-4alkoxyC1-4alkyl;
- fluoroC1-4alkyl, aminoC1-4alkyl, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, C3-6cycloalkyl, —(CH2)pNHCOCH3, —(CH2)pNHSO2CH3, —(CH2)pNHCONH2, —(CH2)pCONR2R3, —(CH2)pNR2R3, —(CH2)pSO2NH2, —(CH2)pSO2NR2R3, —(CH2)pCONH2, —(CH2)pCONR2R3 or —(CH2)p—R7, where
- p is 0, 1, 2 or 3;
- R2 represents hydrogen or C1-3alkyl;
- R3 represents C1-3alkyl;
- and
- R7 represents phenyl;
- R7 represents a 5 or 6 membered monocyclic heteroaryl ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S;
- or
- R7 represents a monocyclic 4, 5, or 6 membered heterocyclic ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S;
- wherein R7 is optionally substituted by 1 or 2 substituents selected from trifluoromethyl, C1-4alkoxy, fluoro, chloro, bromo, and cyano;
- R4 represents hydrogen, fluoro, chloro, bromo, cyano or trifluoromethyl;
- and
- R5 represents hydrogen, fluoro, chloro or bromo.
Dependencies are inferred from the claim text.