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US 11,236,094 B2Granted
Substituted pyrrolo[2,1-f][1,2,4]triazines as FGFR inhibitors
AssigneeCspc Zhongqi Pharmaceuticall Technology (Shijiazhuang) Co., Ltd.
InventorsYikai Wang, Yang Zhang, Zhengxia Chen, Linlin Chen, Tao Feng, Rongxin Huang, Qiu Li, Deyao Li, Jikui Sun, Yangyang Xu, Jie Li, Jian Li, Shuhui Chen
Life of this patent
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Abstract
Provided is a FGFR inhibitor, designating a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. Also provided is the application of a drug for treating solid tumors, such as FGFR related diseases.
Claims20
A compound represented by formula (I):
- or a pharmaceutically acceptable salt or stereoisomer thereof,
- wherein:
- R1 is H, halogen, C1-3 alkyl, C1-3 heteroalkyl, NH2, or OH, wherein the C1-3 alkyl or C1-3 heteroalkyl is optionally substituted with 1, 2, or 3 independently selected R substituents;
- R2 is H, F, Cl, Br, I, NH2, or OH;
- R3 is H, halogen, CN, C1-3 alkyl, C1-3 heteroalkyl, NH2, or OH, wherein the C1-3 alkyl or C1-3 heteroalkyl is optionally substituted with 1, 2, or 3 independently selected R substituents;
- R4 is H, halogen, CN, C1-3 alkyl, C1-3 heteroalkyl, NH2, or OH, wherein the C1-3 alkyl or C1-3 heteroalkyl is optionally substituted with 1, 2, or 3 independently selected R substituents;
- L is a single bond, C2-4 alkenylene, or C2-4 alkynylene;
- R5 is H, C1-3 alkyl, C1-3 heteroalkyl, C3-6 cycloalkyl, or 4- to 6-membered heterocycloalkyl, wherein the C1-3 alkyl, C1-3 heteroalkyl, C3-6 cycloalkyl, or 4- to 6-membered heterocycloalkyl is optionally substituted with 1, 2, or 3 independently selected R substituents;
- R6 is H, halogen, C1-3 alkyl, NH2, or OH, wherein the C1-3 alkyl is optionally substituted with 1, 2, or 3 independently selected R substituents;
- each R is independently F, Cl, Br, I, CN, CH3, CF3, NH2, N(CH3)2, OH, or OCH3;
- and
- m is 1 or 2;
- wherein each heteroatom or each heteroatomic group of each C1-3 heteroalkyl and each 4- to 6-membered heterocycloalkyl is 1, 2, or 3 heteroatoms or heteroatomic groups independently selected from the group consisting of N, —NH—, —O—, and —S—.
10 more elements
Dependencies are inferred from the claim text.