Protein kinase inhibitors
AssigneePrinceton Drug Discovery Inc
InventorKan He
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Abstract
The present invention is directed to novel protein kinase inhibitors comprising the chemical compound N-(2-chloro-6-methylphenyl)-2-[[2-methyl-6-(3-hydroxypyrrolidin-1-yl)pyrimidin-4-yl]amino]thiazole-5-carboxamide, its pharmaceutically acceptable salts, enantiomers, and enantiomeric mixtures, and methods of use to treat protein kinase-mediated diseases or conditions.
Claims18
A method of treating an autoimmune disease or condition selected from systemic lupus erythematosus (SLE), transplant rejection, multiple sclerosis (MS), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS), rheumatoid arthritis (RA), and psoriasis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound having the structure
- and/or a salt, enantiomer, and enantiomeric mixture thereof.
A method of treating an autoimmune disease or condition selected from systemic lupus erythematosus (SLE), transplant rejection, multiple sclerosis (MS), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS), rheumatoid arthritis (RA), and psoriasis in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a compound having the structure
- and/or a salt, enantiomer, and enantiomeric mixture thereof, and at least one pharmaceutically acceptable excipient.
A method of treating an autoimmune disease or condition selected from systemic lupus erythematosus (SLE), transplant rejection, multiple sclerosis (MS), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS), rheumatoid arthritis (RA), and psoriasis in a subject thereof, comprising administering to the subject a therapeutically effective amount of a compound having the structure
- and/or a salt, enantiomer, and enantiomeric mixture thereof, in combination with at least one additional therapeutic agent.
Dependencies are inferred from the claim text.