Reaction medium containing water-surfactant mixture
AssigneeNovartis AG
InventorsFabrice Gallou, Michael Parmentier, Jianguang Zhou, Pengfei Guo
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Abstract
The present invention is directed to reaction mixtures comprising a water-surfactant mixture and a co-solvent. This technology reduced the amount of organic solvents needed for performing chemical reactions. Furthermore, compared to reaction mixtures lacking the co-solvent, solvation of the reactants and products of the chemical reaction is greatly enhanced, leading to a significantly improved yield, purity, reproducibility and robustness.
Claims38
A reaction mixture comprising one or more reactants, a catalyst, an organic solvent, and a surfactant-water mixture, wherein the reaction mixture comprises 0.1 to 50 volume equivalents of the organic solvent, and 1 to 50 volume equivalents of the surfactant-water mixture per mass of the reactants or product, respectively, wherein the surfactant is selected from the group consisting of (DL-α-) tocopherol polyethylene glycol succinate (TPGS), polyethylene glycol ester, Tween, phase transfer surfactants (PTS), polyoxyethanyl ubiquinol sebacate (PQS) and functionalized PQS, polyethylene glycol (PEG), octanoic acid, and b-sitosterol methoxyethyleneglycol succinate (Nok).
Dependencies are inferred from the claim text.