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US 11,236,069 B2Granted
KIF18A inhibitors
AssigneeAmgen Inc.
InventorsNuria A. Tamayo, Abhisek Banerjee, Jian Jeffrey Chen, Jonathan Dante Low, Ana Elena Minatti, Matthew Paul Bourbeau
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Abstract
Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.
Claims25
A compound, selected from the group consisting of:
- Ex. #
- Chemical Structure
- Name
- 1
- N-(2-((1- Hydroxy- 2- methyl- propan- 2- yl)amino)- 6- methyl- pyrimidin- 4-yl)-4- (methyl- sulfonyl)- 2-(6- azaspiro [2.5]octan- 6-yl) benzamide
- 1-7
- N-(2-((1- hydroxy- 2-methy- lpropan- 2-yl)amino)- 6-methyl- pyrimidin- 4- yl)-4-(N- (3-methyl- oxetan-3-yl) sulfamoyl)- 2-(6- azaspiro[2.5] octan-6- yl)benzamide
- 2-8
- N-(2-(4,4- Difluoro- piperidin- 1-yl)-6- methyl- pyrimidin- 4-yl)-4-((1- methyl- cyclo- propane)- 1-sulfon- amido)- 2-(6- azaspiro [2.5] octan-6- yl)benzamide
- 3
- (R)-4-((2- Hydroxy- ethyl) sulfon- amido)-N- (6- methyl-2- (2-methyl- morpholino) pyrimidin-4- yl)-2-(6- azaspiro[2.5] octan-6- yl)benzamide
- 4
- N-(2-(4,4- Difluoro- piperidin- 1-yl)-6- methyl- pyrimidin- 4-yl)-4-((2- hydroxy- ethyl) sulfon- amido)- 2-(6- azaspiro [2.5] octan-6-yl) benzamide
- 5-1
- (R)-N-(2- (4,4- Difluoro- piperidin- 1-yl)-6- methyl- pyrimidin- 4-yl)-4-((2- hydroxy-1- methyl- ethyl) sulfon- amido)- 2-(6- azaspiro [2.5] octan-6- yl)benzamide
- 5-2
- (S)-N-(2- (4,4- Difluoro- piperidin-1- yl)-6- methyl- pyrimidin- 4-yl)-4-((2- hydroxy-1- methyl- ethyl) sulfon- amido)- 2-(6- azaspiro[2.5] octan-6-yl)- benzamide
- 6-35
- N-(2-(4,4- Difluoro- piperidin- 1-yl)-6- methyl- pyrimidin- 4-yl)-4- (ethylsulfo- namido)- 2-(6- azaspiro [2.5] octan-6-yl) benzamide
- 7
- N-(2-(3,3- Difluoro- azetidin- 1-yl)-6- methyl- pyrimidin- 4-yl)-4- ((2- hydroxy- ethyl) sulfon- amido)- 2-(6- azaspiro [2.5] octan-6-yl) benzamide
- 15
- N-(2-(4,4- Difluoro- cyclohexyl)- 6-methyl- pyrimidin- 4-yl)-4-((2- hydroxy- ethyl) sulfon- amido)- 2-(6- azaspiro [2.5] octan-6-yl) benzamide
- 21
- 4-(Azetidin- 3- ylsulfonyl)- N-(2- (4,4-difluoro- piperidin- 1-yl)-6- methyl- pyrimidin- 4-yl)-2-(6- azaspiro [2.5] octan- 6-yl) benzamide;
- or any pharmaceutically-acceptable salt thereof.
23 more elements
Dependencies are inferred from the claim text.