Fused ring compounds

A compound of Formula (III):

• or a pharmaceutically acceptable salt thereof;
• wherein,
• R2 is NH2;
• R3 is H C1-6 alkyl;
• R4 is H or C1-6 alkyl;
• R5 is CF3;
• R10 is selected from the group consisting of R10a and —C(O)—R10a;
• R10a is selected from the group consisting of oxiranyl and aziridinyl;
• X is a 4- to 7-membered heterocyclyl which is optionally substituted with 1 to 4 substituents, wherein each substituent is independently selected from the group consisting of cyano, C1-6 alkyl, C1-6 cyanoalkyl, and C1-6 haloalkyl;
• Y is selected from the group consisting of -L-Y1;
• Y1 dis selected from the group consisting of C1-6 alkyl substituted with a 4- to 10-membered heterocyclyl that is optionally substituted with 1-4 Y1a substituents, C1-6 alkyl substituted with a C1-6 dialkylamino substituent, C1-6 alkyl substituted with a C1-6 dialkylamino cyclopropyl, C3-7 cycloalkyl substituted with a C1-6 dialkylamino, and a 4- to 10-membered heterocyclyl substituted with methyl;
• each Y1a is independently selected from the group consisting of halo, C1-6 alkyl, C1-6 alkoxy, 3- to 7-membered heterocyclyl, C1-6 alkoxyC1-6 alkyl, C1-6 haloalkyl, oxo, hydroxy, NH2, cyano, C1-6 carboxyalkyl, C1-6 cyanoalkyl, C1-6 hydroxyalkyl, and C1-6 haloalkoxy;
• L is O;
• U is C(R6a);
• V is C(R6b);
• W is C(R6c) or N;
• each of R6a, R6b, and R6c are independently selected from the group consisting of H, OH, NH2, halo, cyano, carbamoyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, C1-6 alkyl substituted with a 4- to 10-membered heterocyclyl substituent, C1-6 alkylsulfanyl, C1-6 alkylsulfonyl, C1-6 alkylthio, C1-6 haloalkylthio, C2-6 alkynyl, C1-6 alkylamino, C6-14 aryl, C1-6 aminoalkyl, C1-6 carbamoylalkyl, C1-6 carboxyalkyl, C1-6 cyanoalkyl, C3-7 cycloalkyl, C1-6 haloalkoxy, C1-6 haloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocyclyl;
• and
• n is selected from the group consisting of 0, 1, and 2.

A compound of Formula (IV):

• or a pharmaceutically acceptable salt thereof;
• wherein,
• R1 is selected from the group consisting of:
• R12 is selected from the group consisting of C1-6 alkanoyl, C1-6 alkyl, and C1-6 alkylsulfonyl;
• R13 is selected from the group consisting of H, C1-6 alkyl and C1-6 haloalkyl;
• R13a is halo;
• R14 is halo;
• X is a 4- to 7-membered heterocyclyl, which is optionally substituted with 1 to 4 substituents, wherein each substituent is independently selected from the group consisting of cyano, C1-6 alkyl, C1-6 cyanoalkyl, and C1-6 haloalkyl;
• Y is selected from the group consisting of
• U is C(R6a);
• V is C(R6b);
• W is C(R6b) or N;
• each of R6a, R6b, and R6c are independently selected from the group consisting of H, OH, NH2, halo, cyano, carbamoyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, C1-6 alkyl substituted with a 4- to 10-membered heterocyclyl substituent, C1-6 alkylsulfanyl, C1-6 alkylsulfonyl, C1-6 alkylthio, C1-6 haloalkylthio, C2-6 alkynyl, C1-6 alkylamino, C6-14 aryl, C1-6 aminoalkyl, C1-6 carbamoylalkyl, C1-6 carboxyalkyl, C1-6 cyanoalkyl, C3-7 cycloalkyl, C1-6 haloalkoxy, C1-6 haloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocyclyl;
• n is selected from the group consisting of 0, 1, and 2;
• and
• R11 is selected from the group consisting of:

A compound having a Formula selected from the group consisting of:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R2 is NH2;
• R3 is H;
• R4 is H or C1-6 alkyl;
• R5 is CF3;
• Y is of -L-Y1;
• Y1 is selected from the group consisting of C1-6 alkyl, C1-6 alkyl substituted with a 4- to 10-membered heterocyclyl that is optionally substituted with 1-4 Y1a substituents, C1-6 alkyl substituted with a C1-6 dialkylamino substituent, C1-6 alkyl substituted with a C1-6 dialkylamino cyclopropyl C3-7 cycloalkyl substituted with a C1-6 dialkylamino, and 4- to 10-membered heterocyclyl substituted with methyl;
• each Y1a is independently selected from the group consisting of halo, C1-6 alkyl, C1-6 alkoxy, 3- to 7-membered heterocyclyl, C1-6 alkoxyC1-6 alkyl, C1-6 haloalkyl, oxo, hydroxy, NH2, cyano, C1-6 carboxyalkyl, C1-6 cyanoalkyl, C1-6 hydroxyalkyl, and C1-6 haloalkoxy;
• L is O;
• U is C(R6a);
• V is C(R6b);
• W is C(R6c) or N;
• and
• each of R6a, R6b, and R6c are independently selected from the group consisting of H, OH, NH2, halo, cyano, carbamoyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, C1-6 alkyl substituted with a 4- to 10-membered heterocyclyl substituent, C1-6 alkylsulfanyl, C1-6 alkylsulfonyl, C1-6 alkylthio, C1-6 haloalkylthio, C2-6 alkynyl, C1-6 alkylamino, C6-14 aryl, C1-6 aminoalkyl, C1-6 carbamoylalkyl, C1-6 carboxyalkyl, C1-6 cyanoalkyl, C3-7 cycloalkyl, C1-6 haloalkoxy, C1-6 haloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocyclyl.