Pyridazinone compounds and uses thereof

A compound represented by Formula (I′):

• or a salt thereof, wherein:
• each X is independently selected from C(R3), N, and N+(—O−), wherein at least one X is N or N+(—O−);
• A is selected from —O—, —NR4—, —CR5R6—, —C(O)—, —S—, —S(O)—, and —S(O)2—;
• R1 is selected from:
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —N(R10)2, —C(O)R10, —C(O)N(R10)2, —N(R10)C(O)R10, —C(O)OR10, —OC(O)R10, —N(R10)C(O)N(R10)2, —OC(O)N(R10)2, —N(R10)C(O)OR10, —S(O)R10, —S(O)2R10, —NO2, ═O, ═S, ═N(R10), —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —N(R10)2, —C(O)R10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —OC(O)N(R10)2, —N(R10)C(O)OR10, —C(O)OR10, —OC(O)R10, —S(O)R10, —S(O)2R10, —NO2, ═O, ═S, ═N(R10), —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein the C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9;
• or
• R1 together with R3 form a 5- to 10-membered heterocycle or C5-10 carbocycle, wherein the 5- to 10-membered heterocycle or C5-10 carbocycle is optionally substituted with one or more R9;
• or R1 together with R5 form a 3- to 10-membered heterocycle or C3-10 carbocycle, wherein the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9;
• or R1 together with R4 form a 3- to 10-membered heterocycle, wherein the 3- to 10-membered heterocycle is optionally substituted with one or more R9;
• R25 is selected from:
• hydrogen, and C1-6 alkyl;
• or
• R25 together with R2 form a 3- to 6-membered heterocycle, wherein the 3- to 6-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle;
• R2 is selected from:
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —N(R10)2, —C(O)R10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —OC(O)N(R10)2, —N(R10)C(O)OR10, —C(O)OR10, —OC(O)R10, —S(O)R10, —S(O)2R10, —NO2, ═O, ═S, ═N(R10), —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from:
• halogen, —OR10, —SR10, —N(R10)2, —C(O)R10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —OC(O)N(R10)2, —N(R10)C(O)OR10, —C(O)OR10, —OC(O)R10, —S(O)R10, —S(O)2R10, —NO2, ═O, ═S, ═N(R10), —CN, C1-6 alkyl, and C3-10 carbocycle, wherein the C1-6 alkyl, and C3-10 carbocycle are optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —N(R10)2, —NO2, and —CN;
• or
• R2 together with R25 form a 3- to 6-membered heterocycle, wherein the 3- to 6-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle;
• R3, R5, and R6 are each independently selected from:
• hydrogen, halogen, —OR10, —SR10, —N(R10)2, —NO2, and —CN;
• and
• C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —N(R10)2, —NO2, and —CN;
• or
• R3 together with R1 form a 5- to 10-membered heterocycle or C5-10 carbocycle, wherein the 5- to 10-membered heterocycle or C5-10 carbocycle is optionally substituted with one or more R9;
• or R5 together with R1 form a 3- to 10-membered heterocycle or C3-10 carbocycle, wherein the 3- to 10-membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9;
• R4 is selected from:
• hydrogen;
• and
• C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —N(R10)2, —NO2, and —CN;
• or
• R4 together with R1 form a 3- to 10-membered heterocycle, which is optionally substituted with one or more R9;
• R7 and R8 are each independently selected from:
• halogen, —OR10, —SR10, —N(R10)2, —NO2, —CN, and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —N(R10)2, —NO2, and —CN;
• each R9 is independently selected from:
• halogen, —OR10, —SR10, —N(R10)2, —C(O)R10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —OC(O)N(R10)2, —N(R10)C(O)OR10, —C(O)OR10, —OC(O)R10, —S(O)R10, —S(O)2R10, —NO2, ═O, ═S, ═N(R10), and —CN;
• and
• C1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —N(R10)2, —C(O)R10, —C(O)N(R10)2, —N(R10)C(O)R10, —N(R10)C(O)N(R10)2, —OC(O)N(R10)2, —N(R10)C(O)OR10, —C(O)OR10, —OC(O)R10, —S(O)R10, —S(O)2R10, —NO2, ═O, ═S, ═N(R10), and —CN;
• each R10 is independently selected from:
• hydrogen;
• and
• C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C3-10 carbocycle, and 3- to 10-membered heterocycle;
• and
• C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —CN, —OH, —SH, —NO2, —NH2, ═O, ═S, —O—C1-6 alkyl, —S—C1-6 alkyl, —N(C1-6 alkyl)2, —NH(C1-6 alkyl), C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, 3- to 10-membered heterocycle, and haloalkyl;
• n is 0, 1, or 2;
• and
• p is 0, 1, or 2.