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US 11,236,060 B2Granted
Method for producing solid dispersion containing nobiletin
AssigneeKao Corporation
InventorsMasazumi Iwashita, Takashi Suzuki
Life of this patent
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Abstract
Provided are a nobiletin composition having excellent solubility in water and a method for simply producing the same. A method for producing a solid dispersion containing nobiletin, the method involving a step of dissolving nobiletin or a nobiletin-containing substance and a water-soluble hesperidin derivative selected from the group consisting of glucosyl hesperidin and methyl hesperidin in an ethanol aqueous solution having an ethanol concentration of from 20 to 90 vol % and a step of drying the solution.
Claims3
A method for producing a solid dispersion comprising nobiletin, the method comprising:
- dissolving nobiletin or a nobiletin-comprising substance and a water-soluble methyl hesperidin in an ethanol aqueous solution having an ethanol concentration of from 20 to 90 vol %;
- and
- spray-drying the solution,
- wherein a mass ratio of nobiletin to the water-soluble methyl hesperidin [nobiletin/water-soluble methyl hesperidin], when nobiletin or the nobiletin-comprising substance and the water-soluble methyl hesperidin are mixed, is from 0.01 to 0.67.
1 more element
Dependencies are inferred from the claim text.